Common FTO rs9939609 variant and risk of type 2 diabetes in Palestine
نویسندگان
چکیده
منابع مشابه
Common Variations in Perilipin rs1052700 and FTO rs3751812 Genes, Central Obesity, and Risk Type-2 Diabetes
Background: Perilipins are proteins at the external level of the lipid glob in adipocytes steroid-generating cells and play a central role in lipid storage and breakdown. FTO gene is associated with Type-2 diabetes (T2D) and increased fat mass. Association of Perilipin and FTO genes polymorphism with T2D was investigated. Methods: Clinical traits in a random sample of 183 Iranian men and wom...
متن کاملCommon Variant rs9939609 in Gene FTO Confers Risk to Polycystic Ovary Syndrome
BACKGROUND Fat mass and obesity-associated gene (FTO) has been associated with obesity, especially the common variant rs9939609. Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder and over 50% of patients are overweight/obese. Thus FTO is a potential candidate gene for PCOS but their relationship is confusing and remains to be clarified in different population with a lar...
متن کاملCommon Variant of FTO Gene, rs9939609, and Obesity in Pakistani Females
Numerous studies confirmed the association of FTO (fat mass and obesity associated gene) common variant, rs9939609, with obesity in European populations. However, studies in Asian populations revealed conflicting results. We examined the association of rs9939609 variant of FTO gene with obesity and obesity-related anthropometric and metabolic parameters in Pakistani population. Body weight, hei...
متن کاملAssociation between ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133), FTO (rs9939609) Gene Polymorphism and Type 2 Diabetes with Dyslipidemia
Diabetic dyslipidemia is one of the leading causes of coronary artery disease (CAD) death. Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (T2DM) and dyslipidemia. The present study was aimed to investigate the association of ACE (rs4646994), FABP2 (rs1799883), MTHFR (rs1801133) and FTO (rs9939609) genetic polymorphism in T2DM with dyslipi...
متن کاملASSOCIATION ANALYSIS BETWEEN RS10830962 VARIANT OF MTNR1B GENE AND TYPE 2 DIABETES MELLITUS RISK
Background: Type 2 diabetes mellitus (T2DM) is the most common type of diabetes that was classically characterized by pancreatic β-cell dysfunction. Changes in circadian patterns is one of the reasons which can increase the occurrence of diabetes. Melatonin is one of the biological molecules which plays an important role in regulating the circadian clock and also an inhibitory effect on insulin...
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ژورنال
عنوان ژورنال: BMC Medical Genetics
سال: 2018
ISSN: 1471-2350
DOI: 10.1186/s12881-018-0668-8